BD-PT6144

CDH3 Rabbit Polyclonal Antibody

Cadherin-3 (Placental cadherin) (P-cadherin)

常规抗体

CDH3 CDHP

Cadherin-3 (Placental cadherin) (P-cadherin)

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

1001

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1001

P22223

http://www.uniprot.org/uniprotkb/P22223/entry

12560

P10287

http://www.uniprot.org/uniprot/P10287

Synthesized peptide derived from human CDH3 Polyclonal

This antibody detects endogenous levels of CDH3.

WB 1:500-2000, ELISA 1:10000-20000

120kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015],

Expressed in some normal epithelial tissues and in some carcinoma cell lines.

Cell membrane; Single-pass type I membrane protein.

Cell adhesion molecules (CAMs);

disease:Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM) [MIM:225280]; also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EEM is an autosomal recessive condition characterized by features of ectodermal dysplasia such as sparse eyebrows and scalp hair, and selective tooth agenesis associated with macular dystrophy and ectrodactyly.,disease:Defects in CDH3 are the cause of hypotrichosis with juvenile macular dystrophy (HJMD) [MIM:601553]. HJMD is a rare autosomal recessive disorder characterized by early hair loss heralding severe degenerative changes of the retinal macula and culminating in blindness during the second to third decade of life.,function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.,online information:Retina International's Scientific Newsletter,similarity:Contains 5 cadherin domains.,subunit:Interacts with CDCP1.,tissue specificity:Expressed in some normal epithelial tissues and in some carcinoma cell lines.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.