产品名称
VPS18 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/57617
Human Swissprot No.
Q9P253
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9P253/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/228545
Mouse Swissprot No.
Q8R307
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R307
免疫原
Synthesized peptide derived from human VPS18 AA range: 778-828
特异性
This antibody detects endogenous levels of VPS18 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Expression was highest in heart and low in lung.
细胞定位
Late endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Early endosome . Cytoplasmic vesicle, autophagosome . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasmic, peripheral membrane protein associated with early endosomes and late endosomes/lysosomes.
功能
function:May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes.,similarity:Belongs to the VPS18 family.,similarity:Contains 1 clathrin repeat.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes.,subunit:Interacts with HOOK1 (By similarity). Large hetero-oligomeric complex together with VPS11, VPS16 and VPS33A. Interacts with STX7.,tissue specificity:Ubiquitous. Expression was highest in heart and low in lung.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
