产品名称
C8 α Rabbit Polyclonal Antibody
别名
Complement component C8 alpha chain (Complement component 8 subunit alpha)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=731
Human Swissprot No.
P07357
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P07357/entry
Mouse Swissprot No.
Q8K182
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K182
免疫原
Synthesized peptide derived from human C8 α. at AA range: 201-250
特异性
C8 α Polyclonal Antibody detects endogenous levels of C8 α
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008],
细胞定位
Secreted. Cell membrane; Multi-pass membrane protein. Secreted as soluble protein. Inserts into the cell membrane of target cells.
信号通路
Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;
功能
disease:Defects in C8A are a cause of complement C8 deficiency type I [MIM:120950]. Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C8 is a constituent of the membrane attack complex. C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 TSP type-1 domains.,subunit:C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
