产品名称
MYL2 Rabbit Polyclonal Antibody
别名
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4633
Human Swissprot No.
P10916
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P10916/entry
Mouse Swissprot No.
P51667
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51667
免疫原
Synthesized peptide derived from human MYL2. at AA range: 91-140
特异性
MYL2 Polyclonal Antibody detects endogenous levels of MYL2
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],
组织表达
Highly expressed in type I muscle fibers.
细胞定位
Cytoplasm, myofibril, sarcomere, A band .
信号通路
Cardiac muscle contraction;Focal adhesion;Tight junction;Leukocyte transendothelial migration;Regulates Actin and Cytoskeleton;Hypertrophic cardiomyopathy (HCM);Dilated cardiomyopathy;
功能
disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand domains.,subunit:Myosin is an hexamer of 2 heavy chains and 4 light chains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
