产品名称
V-ATPase S1 Rabbit Polyclonal Antibody
别名
V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=537
Human Swissprot No.
Q15904
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15904/entry
Mouse Swissprot No.
Q9R1Q9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R1Q9
免疫原
Synthesized peptide derived from human V-ATPase S1. at AA range: 421-470
特异性
V-ATPase S1 Polyclonal Antibody detects endogenous levels of V-ATPase S1
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013],
组织表达
widely expressed, with highest levels in brain and lowest in liver and duodenum.
细胞定位
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum-Golgi intermediate compartment membrane . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass type I membrane protein . Not detected in trans-Golgi network. .
信号通路
Oxidative phosphorylation;Lysosome;Vibrio cholerae infection;Epithelial cell signaling in Helicobacter pylori infection;
功能
function:Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the vacuolar ATPase subunit S1 family.,subunit:Composed of at least 10 subunits.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
