产品名称
Transferrin(10G3)Mouse Monoclonal Antibody
别名
TF; Serotransferrin; Transferrin; Beta-1 metal-binding globulin; Siderophilin
蛋白名称
Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7018
Human Swissprot No.
P02787
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P02787/entry
Mouse Swissprot No.
Q921I1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q921I1
特异性
Transferrin protein detects endogenous levels of Transferrin
稀释度
WB 1:2000-5000, IHC 1:100-200. IF 1:50-200
背景介绍
transferrin(TF) Homo sapiens This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009],
组织表达
Expressed by the liver and secreted in plasma.
功能
disease:Defects in TF are the cause of atransferrinemia [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.,function:Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.,online information:Transferrin entry,polymorphism:Different polymorphic variants of transferrin are known. The sequence shown is the predominant electrophoretic variant (C1 or TF*C1).,similarity:Belongs to the transferrin family.,similarity:Contains 2 transferrin-like domains.,subunit:Monomer.,tissue specificity:Expressed by the liver and secreted in plasma.,
纯化
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
