产品名称
IL-8RA Rabbit Polyclonal Antibody
别名
C-X-C chemokine receptor type 1 (CXC-R1;CXCR-1;CDw128a;High affinity interleukin-8 receptor A;IL-8R A;IL-8 receptor type 1;CD antigen CD181)
蛋白名称
C-X-C chemokine receptor type 1 (CXC-R1) (CXCR-1) (CDw128a) (High affinity interleukin-8 receptor A) (IL-8R A) (IL-8 receptor type 1) (CD antigen CD181)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3577
Human Swissprot No.
P25024
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P25024/entry
Mouse Swissprot No.
Q810W6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q810W6
免疫原
Synthetic peptide from human protein at AA range: 1-50
特异性
The antibody detects endogenous IL-8RA
稀释度
WB 1:500-2000 IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
C-X-C motif chemokine receptor 1(CXCR1) Homo sapiens The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008],
细胞定位
Cell membrane; Multi-pass membrane protein.
信号通路
Cytokine-cytokine receptor interaction;Chemokine;Endocytosis;Epithelial cell signaling in Helicobacter pylori infection;
功能
function:Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.,online information:CXC chemokine receptors entry,similarity:Belongs to the G-protein coupled receptor 1 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
