产品名称
PF-4 Rabbit Polyclonal Antibody
别名
Platelet factor 4 (PF-4;C-X-C motif chemokine 4;Iroplact;Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
蛋白名称
Platelet factor 4 (PF-4) (C-X-C motif chemokine 4) (Iroplact) (Oncostatin-A) [Cleaved into: Platelet factor 4, short form]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5196
Human Swissprot No.
P02776
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P02776/entry
Mouse Swissprot No.
Q9Z126
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9Z126
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P06765
免疫原
Synthetic peptide from human protein at AA range: 51-100
特异性
The antibody detects endogenous PF-4
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014],
信号通路
Cytokine-cytokine receptor interaction;Chemokine;
功能
function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.,mass spectrometry: PubMed:7644496,mass spectrometry:Short form PubMed:7644496,online information:CXCL4 entry,PTM:Binds non-covalently to a proteoglycan molecule.,similarity:Belongs to the intercrine alpha (chemokine CxC) family.,subunit:Homotetramer.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
