产品名称
GSTA1 Rabbit Polyclonal Antibody
别名
Glutathione S-transferase A1 (EC 2.5.1.18;GST HA subunit 1;GST class-alpha member 1;GST-epsilon;GSTA1-1;GTH1)
蛋白名称
Glutathione S-transferase A1 (EC 2.5.1.18) (GST HA subunit 1) (GST class-alpha member 1) (GST-epsilon) (GSTA1-1) (GTH1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2938
Human Swissprot No.
P08263
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P08263/entry
Mouse Swissprot No.
P13745
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P13745
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human GSTA1. AA range:91-140
特异性
The antibody detects endogenous GSTA1
稀释度
WB 1:500-2000 IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of a family of enzymes that function to add glutathione to target electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. This action is an important step in detoxification of these compounds. This subfamily of enzymes has a particular role in protecting cells from reactive oxygen species and the products of peroxidation. Polymorphisms in this gene influence the ability of individuals to metabolize different drugs. This gene is located in a cluster of similar genes and pseudogenes on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
信号通路
Glutathione metabolism;Metabolism of xenobiotics by cytochrome P450;Drug metabolism;
功能
catalytic activity:RX + glutathione = HX + R-S-glutathione.,domain:The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.,function:Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.,similarity:Belongs to the GST superfamily.,similarity:Belongs to the GST superfamily. Alpha family.,similarity:Contains 1 GST C-terminal domain.,similarity:Contains 1 GST N-terminal domain.,subunit:Homodimer or heterodimer of GSTA1 and GSTA2.,tissue specificity:Liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
