产品名称
TGFβ2 Rabbit Polyclonal Antibody
别名
Transforming growth factor beta-2 (TGF-beta-2;BSC-1 cell growth inhibitor;Cetermin;Glioblastoma-derived T-cell suppressor factor;G-TSF;Polyergin)
蛋白名称
Transforming growth factor beta-2 (TGF-beta-2) (BSC-1 cell growth inhibitor) (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) (Polyergin)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7042
Human Swissprot No.
P61812
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P61812/entry
Mouse Swissprot No.
P27090
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P27090
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q07257
免疫原
The antiserum was produced against synthesized peptide derived from human TGF beta2. AA range:361-410
特异性
The antibody detects endogenous TGFβ2
稀释度
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the an
组织表达
Aorta endothelial cell,Lung,
细胞定位
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix .; [Transforming growth factor beta-2]: Secreted .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Cytokine-cytokine receptor interaction;Cell_Cycle_G1S;Cell_Cycle_G2M_DNA;TGF-beta;Intestinal immune network for IgA production;Pathways in cancer;Colorectal cancer;Renal cell carcinoma;Pancreatic cancer;Chronic myeloid leuke
功能
disease:A chromosomal aberration involving TGFB2 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with HDAC9. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.,function:TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.,online information:TGF beta-2 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
