产品名称
CD64 Rabbit Polyclonal Antibody
别名
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I;Fc-gamma RI;FcRI;Fc-gamma RIA;FcgammaRIa;CD antigen CD64)
基因名称
FCGR1A FCG1 FCGR1 IGFR1
蛋白名称
High affinity immunoglobulin gamma Fc receptor I (IgG Fc receptor I) (Fc-gamma RI) (FcRI) (Fc-gamma RIA) (FcgammaRIa) (CD antigen CD64)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2209
Human Swissprot No.
P12314
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P12314/entry
Mouse Swissprot No.
P26151
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P26151
免疫原
Synthetic peptide from human protein at AA range: 230-280
特异性
The antibody detects endogenous CD64
稀释度
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq, Jul 2008],
组织表达
Monocyte/macrophage specific.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Stabilized at the cell membrane through interaction with FCER1G.
信号通路
Hematopoietic cell lineage;Fc gamma R-mediated phagocytosis;Systemic lupus erythematosus;
功能
function:High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.,online information:FCGR1A mutation db,PTM:N-glycosylated.,PTM:Phosphorylated on serine residues.,similarity:Belongs to the immunoglobulin superfamily. FCGR1 family.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,subcellular location:Stabilized at the cell membrane through interaction with FCER1G.,subunit:Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL.,tissue specificity:Monocyte/macrophage specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
