产品名称
CD168 Rabbit Polyclonal Antibody
别名
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility;CD antigen CD168)
蛋白名称
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3161
Human Swissprot No.
O75330
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75330/entry
Mouse Swissprot No.
Q00547
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q00547
免疫原
Synthetic peptide from human protein at AA range: 280-340
特异性
The antibody detects endogenous CD168
稀释度
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008],
组织表达
Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751).
细胞定位
Cell surface . Cytoplasm . Cytoplasm, cytoskeleton, spindle .
信号通路
ECM-receptor interaction;
功能
function:Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.,subunit:Subunit of the HARC complex.,tissue specificity:Expressed in breast cancer cell lines and in normal breast tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
