产品名称
MFN1 Rabbit Polyclonal Antibody
别名
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.12% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55669
Human Swissprot No.
Q8IWA4
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q8IWA4/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/67414
Mouse Swissprot No.
Q811U4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q811U4
Rat Gene Link
https://www.uniprot.org/uniprot/192647
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R4Z9
免疫原
Synthesized peptide derived from human MFN1 AA range: 163-213
特异性
This antibody detects endogenous levels of MFN1 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008],
组织表达
Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411).
细胞定位
Mitochondrion outer membrane ; Multi-pass membrane protein .; [Isoform 2]: Cytoplasm .
功能
catalytic activity:GTP + H(2)O = GDP + phosphate.,function:Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.,similarity:Belongs to the mitofusin family.,subunit:Forms homomultimers and heteromultimers with MFN2. Multimerization, which is probably mediated by the coiled coil region, may play an essential role in mitochondrion fusion (By similarity). Participates in a high molecular weight multiprotein complex.,tissue specificity:Ubiquitous. Expressed at slightly higher level in kidney and heart. Isoform 2 may be overexpressed in some tumors, such as lung cancers.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
