产品名称
Cystatin A Rabbit Polyclonal Antibody
别名
Cystatin-A (Cystatin-AS;Stefin-A)
蛋白名称
Cystatin-A (Cystatin-AS) (Stefin-A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1475
Human Swissprot No.
P01040
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P01040/entry
Mouse Swissprot No.
P56567
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P56567
免疫原
Synthetic peptide from human protein at AA range: 60-98
特异性
The antibody detects endogenous Cystatin A
稀释度
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008],
组织表达
Expressed in the skin throughout the epidermis.
功能
function:This is an intracellular thiol proteinase inhibitor.,similarity:Belongs to the cystatin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.