产品名称
CD168 Rabbit Polyclonal Antibody
别名
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein;Receptor for hyaluronan-mediated motility;CD antigen CD168)
蛋白名称
Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3161
Human Swissprot No.
O75330
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75330/entry
Mouse Swissprot No.
Q00547
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q00547
免疫原
Synthetic peptide from human protein at AA range: 280-340
特异性
The antibody detects endogenous CD168
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008],
组织表达
Expressed in testis (PubMed:22965910). Expressed in the breast (PubMed:8890751).
细胞定位
Cell surface . Cytoplasm . Cytoplasm, cytoskeleton, spindle .
信号通路
ECM-receptor interaction;
功能
function:Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the focal adhesion kinase occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.,subunit:Subunit of the HARC complex.,tissue specificity:Expressed in breast cancer cell lines and in normal breast tissue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
