产品名称
TMEPAI Rabbit Polyclonal Antibody
别名
Transmembrane prostate androgen-induced protein (Solid tumor-associated 1 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56937
Human Swissprot No.
Q969W9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q969W9/entry
Mouse Swissprot No.
Q9D7R2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D7R2
免疫原
Synthetic peptide from human protein at AA range: 240-287
特异性
The antibody detects endogenous TMEPAI
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
组织表达
Highest expression in prostate. Also expressed in ovary.
细胞定位
Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
功能
domain:The WW-binding motifs mediate interaction with NEDD4.,induction:By androgen.,similarity:Belongs to the PMEPA1 family.,subunit:Interacts with the WW domains of NEDD4.,tissue specificity:Highest expression in prostate. Also expressed in ovary.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
