产品名称
DCT Rabbit Polyclonal Antibody
别名
L-dopachrome tautomerase (DCT;DT;EC 5.3.3.12;L-dopachrome Delta-isomerase;Tyrosinase-related protein 2;TRP-2;TRP2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1638
Human Swissprot No.
P40126
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P40126/entry
Mouse Swissprot No.
P29812
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P29812
免疫原
Synthetic peptide from human protein at AA range: 232-304
特异性
The antibody detects endogenous DCT
稀释度
WB 1:500-2000,IHC-p 1:500-200, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,
组织表达
Liver,Lymphnode melanoma metastases,Mammary gland,Melanoma,
细胞定位
Melanosome membrane ; Single-pass type I membrane protein . Melanosome . Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38. .
信号通路
Tyrosine metabolism;Melanogenesis;
功能
catalytic activity:L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.,cofactor:Binds 2 zinc ions per subunit.,function:Involved in regulating eumelanin and phaeomelanin levels.,pathway:Pigment biosynthesis; melanin biosynthesis.,similarity:Belongs to the tyrosinase family.,subunit:Tyrosinase, TYRP1 and TYRP2 may form a multienzyme complex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
