产品名称
ST6GAL1 Rabbit Polyclonal Antibody
别名
Beta-galactoside alpha-2,6-sialyltransferase 1 (Alpha 2,6-ST 1;EC 2.4.99.1;B-cell antigen CD75;CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1;ST6Gal I;ST6GalI;Sialyltransferase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6480
Human Swissprot No.
P15907
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P15907/entry
Mouse Swissprot No.
Q64685
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q64685
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P13721
免疫原
Synthetic peptide from human protein at AA range: 63-135
特异性
The antibody detects endogenous ST6GAL1
稀释度
IHC-p 1:50-200, ELISA 1:10000-20000,WB 1:500-2000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described. [provided by RefSeq, Aug 2009],
组织表达
Liver,Lymph,Placenta,Skin,Spleen,Thymus,
细胞定位
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein . Secreted. Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
信号通路
N-Glycan biosynthesis;
功能
catalytic activity:CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.,function:Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates.,online information:GlycoGene database,online information:ST6Gal I,pathway:Protein modification; protein glycosylation.,PTM:The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.,PTM:The soluble form derives from the membrane form by proteolytic processing.,similarity:Belongs to the glycosyltransferase 29 family.,subcellular location:Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
