产品名称
EIF3H Rabbit Polyclonal Antibody
别名
Eukaryotic translation initiation factor 3 subunit H (eIF3h) (Eukaryotic translation initiation factor 3 subunit 3) (eIF-3-gamma) (eIF3 p40 subunit)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.16% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/8667
Human Swissprot No.
O15372
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O15372/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/68135
Mouse Swissprot No.
Q91WK2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91WK2
Rat Gene Link
https://www.uniprot.org/uniprot/100911110
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P9U8
免疫原
Synthesized peptide derived from human EIF3H AA range: 219-269
特异性
This antibody detects endogenous levels of EIF3H at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
组织表达
Adipose tissue,Cerebellum,Epithelium,Liver,Lung,Pituitary,
功能
function:Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.,mass spectrometry: PubMed:17322308,mass spectrometry: PubMed:18599441,similarity:Belongs to the eIF-3 subunit H family.,similarity:Contains 1 MPN (JAB/Mov34) domain.,subunit:Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of FRAP1 and RAPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
