产品名称
IL-31 Rabbit Polyclonal Antibody
别名
Interleukin-31 (IL-31)
蛋白名称
Interleukin-31 (IL-31)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=386653
Human Swissprot No.
Q6EBC2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6EBC2/entry
Mouse Swissprot No.
Q6EAL8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6EAL8
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human IL31. AA range:21-70
特异性
The antibody detects endogenous IL-31
稀释度
WB 1:500-2000, IHC-p 1:50-200 ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008],
组织表达
Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.
功能
function:Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL31 may function in skin immunity.,induction:Up-regulated in skin homing T-cells of patients with atopic dermatitis (AD) and in activated circulating T-cells. Up-regulated in lesional biopsies of patients with allergic contact dermatitis (ACD).,tissue specificity:Detected at low levels in testis, bone marrow, skeletal muscle, kidney, colon, thymus, small intestine and trachea.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
