产品名称
RSK3 Rabbit Polyclonal Antibody
别名
RPS6KA2 MAPKAPK1C RSK3
基因名称
RPS6KA2 MAPKAPK1C RSK3
蛋白名称
ribosomal protein S6 kinase, 90kDa, polypeptide 2; hypothetical LOC100127984
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6196
Human Swissprot No.
Q15349
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15349/entry
Mouse Swissprot No.
Q9WUT3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WUT3
免疫原
Synthetic peptide from human protein at AA range: 330-400
特异性
The antibody detects endogenous RSK3 protein
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
ribosomal protein S6 kinase A2(RPS6KA2) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016],
组织表达
Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
细胞定位
Nucleus . Cytoplasm .
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Oocyte meiosis;mTOR;Long-term potentiation;Neurotrophin;Progesterone-mediated oocyte maturation;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-377, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,tissue specificity:Expressed in many tissues. Highest expression in lung and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
