产品名称
IRS2 Rabbit Polyclonal Antibody
蛋白名称
insulin receptor substrate 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8660
Human Swissprot No.
Q9Y4H2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y4H2/entry
Mouse Swissprot No.
P81122
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P81122
免疫原
Synthetic peptide from human protein at AA range: 660-700
特异性
The antibody detects endogenous IRS2 protein
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008],
组织表达
Blood,Epithelium,Platelet,
细胞定位
Cytoplasm, cytosol .
信号通路
Neurotrophin;Insulin_Receptor;Adipocytokine;Type II diabetes mellitus;Aldosterone-regulated sodium reabsorption;
功能
function:May mediate the control of various cellular processes by insulin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
