产品名称
PENK Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5179
Human Swissprot No.
P01210
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P01210/entry
Mouse Swissprot No.
P22005
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P22005
免疫原
Synthetic peptide from human protein at AA range: 51-100
特异性
The antibody detects endogenous PENK protein
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015],
组织表达
Brain,Cerebellum,Testis,
细胞定位
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen . Secreted .
功能
function:Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.,PTM:The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.,similarity:Belongs to the opioid neuropeptide precursor family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
