产品名称
HSH2D Rabbit Polyclonal Antibody
别名
Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.18% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/84941
Human Swissprot No.
Q96JZ2
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96JZ2/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/209488
Mouse Swissprot No.
Q6VYH9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6VYH9
免疫原
Synthesized peptide derived from human HSH2D AA range: 288-338
特异性
This antibody detects endogenous levels of HSH2D at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
T-cell activation requires 2 signals: recognition of antigen by the T-cell receptor (see TCR; MIM 186880) and a costimulatory signal provided primarily by CD28 (MIM 186760) in naive T cells. HSH2 is a target of both of these signaling pathways (Greene et al., 2003 [PubMed 12960172]).[supplied by OMIM, Mar 2008],
组织表达
Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta.
功能
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.,PTM:May be phosphorylated by FES and ACK1.,similarity:Contains 1 SH2 domain.,subunit:Interacts with FES and TNK2.,tissue specificity:Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
