产品名称
MYOZ2 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51778
Human Swissprot No.
Q9NPC6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NPC6/entry
Mouse Swissprot No.
Q9JJW5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JJW5
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human MYOZ2. AA range:21-70
特异性
The antibody detects endogenous MYOZ2 protein
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. [provided by RefSeq, Aug 2011],
组织表达
Expressed specifically in heart and skeletal muscle.
细胞定位
Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. .
功能
function:Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.,similarity:Belongs to the myozenin family.,subcellular location:Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle.,subunit:Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ATCN1, LDB3, MYOT and PPP3CA.,tissue specificity:Expressed specifically in heart and skeletal muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
