产品名称
ZFP91 Rabbit Polyclonal Antibody
蛋白名称
zinc finger protein 91 homolog (mouse); ZFP91-CNTF readthrough transcript; ciliary neurotrophic factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80829
Human Swissprot No.
Q96JP5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96JP5/entry
Mouse Swissprot No.
Q62511
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62511
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human ZFP91. AA range:401-450
特异性
The antibody detects endogenous ZFP91 protein
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010],
组织表达
Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.
信号通路
Cytokine-cytokine receptor interaction;Jak_STAT;
功能
disease:Overexpressed in most acute myelogenous leukemia (AML) cases (27 over 29).,function:CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.,function:May be involved in transcriptional regulation. May play an important role in cell proliferation and/or anti-apoptosis.,online information:Ciliary neurotrophic factor entry,similarity:Belongs to the CNTF family.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,subunit:Homodimer.,tissue specificity:Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific.,tissue specificity:Nervous system.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
