BD-PT5822

CYP26B1 Rabbit Polyclonal Antibody

CYP26B1 CYP26A2 P450RAI2

常规抗体

CYP26B1 CYP26A2 P450RAI2

cytochrome P450, family 26, subfamily B, polypeptide 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

56603

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56603

Q9NR63

http://www.uniprot.org/uniprotkb/Q9NR63/entry

232174

Q811W2

http://www.uniprot.org/uniprot/Q811W2

G3V7X8

http://www.uniprot.org/uniprot/O54941G3V7X8

Synthetic peptide from human protein at AA range: 391-440

The antibody detects endogenous CYP26B1 protein

WB 1:500-2000, ELISA 1:10000-20000

60kD

-20°C/1 year

Polyclonal, Rabbit,IgG

cytochrome P450 family 26 subfamily B member 1(CYP26B1) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013],

Highly expressed in brain, particularly in the cerebellum and pons.

Endoplasmic reticulum membrane ; Peripheral membrane protein . Microsome membrane ; Peripheral membrane protein .

Retinol metabolism;

cofactor:Heme group.,enzyme regulation:Has a preferred activity toward the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA.,function:Plays a key role in retinoic acid metabolism. Involved in the specific inactivation of all-trans-retinoic acid (RA). Responsible for generation of several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA.,induction:By retinoic acid.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Highly expressed in brain, particularly in the cerebellum and pons.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.