产品名称
KERA Rabbit Polyclonal Antibody
别名
Keratocan (KTN) (Keratan sulfate proteoglycan keratocan)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.19% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/11081
Human Swissprot No.
O60938
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O60938/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/16545
Mouse Swissprot No.
O35367
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O35367
免疫原
Synthesized peptide derived from human KERA AA range: 26-76
特异性
This antibody detects endogenous levels of KERA at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010],
组织表达
Cornea (at protein level) (PubMed:10802664, PubMed:11683372). Increased expression in the stroma of keratoconus corneas (PubMed:11683372). Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen (PubMed:10802664).
细胞定位
Secreted, extracellular space, extracellular matrix .
功能
disease:Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2) [MIM:217300]. In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population.,disease:Increased expression in the stroma of keratoconus corneas. Keratoconus is a noninflammatory disease characterized by thinning and scarring of the central portion of the cornea.,function:May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.,PTM:Binds keratan sulfate chains.,similarity:Belongs to the small leucine-rich proteoglycan (SLRP) family. Class II subfamily.,similarity:Contains 12 LRR (leucine-rich) repeats.,tissue specificity:Cornea. Also detected in trachea, and in low levels, in intestine, skeletal muscle, ovary, lung and putamen.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
