产品名称
MBL-C Rabbit Polyclonal Antibody
蛋白名称
mannose-binding lectin (protein C) 2, soluble (opsonic defect)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4153
Human Swissprot No.
P11226
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P11226/entry
Mouse Swissprot No.
P41317
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P41317
免疫原
Synthetic peptide from human protein at AA range: 21-70
特异性
The antibody detects endogenous MBL-C protein
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008],
组织表达
Plasma protein produced mainly in the liver.
信号通路
Complement and coagulation cascades;
功能
disease:Genetic variations in MBL2 are associated with susceptibility to hepatitis B virus infection (HBV infection) [MIM:610424]. Approximately one third of all cases of cirrhosis and half of all cases of hepatocellular carcinoma can be attributed to chronic HBV infection. HBV infection may result in subclinical or asymptomatic infection, acute self-limited hepatitis, or fulminant hepatitis requiring liver transplantation.,disease:There is an association between low levels of MBL2 and a defect of opsonization which results in susceptibility to frequent and chronic infections.,function:Binds mannose and N-acetylglucosamine in a calcium-dependent manner. Is capable of host defense against pathogens, by activating the classical complement pathway independently of the antibody.,online information:Mannose-binding protein,similarity:Contains 1 C-type lectin domain.,similarity:Contains 1 collagen-like domain.,subunit:Oligomeric complex of 6 set of homotrimers. Interacts with MASP1 and MASP2; the interaction is calcium-dependent.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
