产品名称
RCC1 Rabbit Polyclonal Antibody
蛋白名称
regulator of chromosome condensation 1; SNHG3-RCC1 readthrough transcript
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1104
Human Swissprot No.
P18754
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P18754/entry
Mouse Swissprot No.
Q8VE37
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VE37
免疫原
Synthetic peptide from human protein at AA range: 301-350
特异性
The antibody detects endogenous RCC1 protein
稀释度
WB 1:500-2000,IHC-p 1:50-200 ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Patients with Raynaud disease produce antibodies that bind to RCC1.,function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.,similarity:Contains 7 RCC1 repeats.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.,
组织表达
Brain,Breast,Epithelium,Eye,Muscle,Testis,
细胞定位
Nucleus . Chromosome . Cytoplasm . Predominantly nuclear in interphase cells (PubMed:12194828). Binds to mitotic chromosomes (PubMed:12194828, PubMed:17435751, PubMed:20668449). .
功能
disease:Patients with Raynaud disease produce antibodies that bind to RCC1.,function:Promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds to the chromatin. RCC1/Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA.,similarity:Contains 7 RCC1 repeats.,subcellular location:Becomes dispersed throughout the cytoplasm during mitosis.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
