产品名称
HSP90 α(1F6)Mouse Monoclonal Antibody
别名
Heat shock protein HSP 90-alpha (Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38)
蛋白名称
Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3320
Human Swissprot No.
P07900
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P07900/entry
Mouse Swissprot No.
P07901
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P07901
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P82995
免疫原
Synthesized peptide derived from the C-terminal region of human HSP90A. at AA range: 660-740
特异性
The antibody detects endogenous HSP90 α protein
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
背景介绍
The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
组织表达
Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius
细胞定位
Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
信号通路
Antigen processing and presentation;NOD-like receptor;Progesterone-mediated oocyte maturation;Pathways in cancer;Prostate cancer;
功能
caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
纯化
The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
