产品名称
ULK2 Rabbit Polyclonal Antibody
蛋白名称
unc-51-like kinase 2 (C. elegans)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9706
Human Swissprot No.
Q8IYT8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8IYT8/entry
Mouse Swissprot No.
Q9QY01
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QY01
免疫原
Synthetic peptide from human protein at AA range: 930-1000
特异性
The antibody detects endogenous ULK2 protein
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
unc-51 like autophagy activating kinase 2(ULK2) Homo sapiens This gene encodes a protein that is similar to a serine/threonine kinase in C. elegans which is involved in axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/serine rich (PS) domain, and a C-terminal (C) domain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Dec 2008],
细胞定位
Cytoplasmic vesicle membrane ; Peripheral membrane protein . Localizes to pre-autophagosomal membrane.
信号通路
Regulation of autophagy;mTOR;
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
