产品名称
PDLI2 Rabbit Polyclonal Antibody
别名
PDZ and LIM domain protein 2 (PDZ-LIM protein mystique)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.22% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/64236
Human Swissprot No.
Q96JY6
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96JY6/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/213019
Mouse Swissprot No.
Q8R1G6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R1G6
Rat Gene Link
https://www.uniprot.org/uniprot/290354
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYD6
免疫原
Synthesized peptide derived from human PDLI2 AA range: 190-240
特异性
This antibody detects endogenous levels of PDLI2 at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011],
组织表达
Epithelium,Hypothalamus,Placenta,Spleen,
细胞定位
Cytoplasm . Nucleus . May be partially nuclear.; [Isoform 1]: Cytoplasm, cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).; [Isoform 2]: Cytoplasm, cytoskeleton.; [Isoform 3]: Nucleus.
功能
function:Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).,subcellular location:May be partially nuclear.,subunit:Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
