Cn|En

现货抗体产品库

SPOP Rabbit Polyclonal Antibody

产品详情 相关文献 产品问答 相关产品

产品基本信息

产品货号
BD-PT5804
产品名称
SPOP Rabbit Polyclonal Antibody
别名
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
类别
常规抗体
基因名称
SPOP
蛋白名称
SPOP
推荐应用
WB
反应种属
Human,Mouse,Rat
浓度
1 mg/ml
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene ID
8405
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8405
Human Swissprot No.
O43791
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43791/entry
Mouse Gene ID
20747
Mouse Swissprot No.
Q6ZWS8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6ZWS8
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human SPOP. AA range:41-90
特异性
SPOP Polyclonal Antibody detects endogenous levels of SPOP
稀释度
WB 1:500-2000;IHC-p 1:50-300
预测分子量
42kD
运输及保存条件
-20°C/1 year
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
组织表达
Widely expressed.
细胞定位
Nucleus . Nucleus speckle .
功能
domain:The MATH domain interacts with H2AFY and BMI1.,function:Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.,miscellaneous:Antigen recognized by serum from scleroderma patient.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the Tdpoz family.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 1 MATH domain.,subunit:Homodimer. Part of a complex consisting of BMI1, CUL3 and SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. Interacts with H2AFY, IPF1/PDX1, BMI1 and DAXX. Interacts with CUL3.,tissue specificity:Widely expressed.,
期货
现货
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Western Blot analysis of 3T3 HEPG2 Hela cells using SPOP Polyclonal Antibody diluted at 1:1500. Secondary antibody was diluted at 1:20000

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200

Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200

相关文献

产品问答

相关产品

免责声明| 法律支持| 联系方式

市场:027-65023363   行政/人事:027-62439686   邮箱:marketing@brainvta.com  

销售总监:张经理  18995532642  华东区:陈经理 18013970337   华南区:王经理 13100653525   华中/西区:杨经理 18186518905   华北区:张经理 18893721749

地址:中国武汉东湖高新区光谷七路128号中科开物产业园1号楼

Copyright © 武汉枢密脑科学技术有限公司. All RIGHTS RESERVED.
鄂ICP备2021009124号 DIGITAL BY VTHINK