产品名称
NLRX1 Rabbit Polyclonal Antibody
别名
NLR family member X1 (Caterpiller protein 11.3;CLR11.3;Nucleotide-binding oligomerization domain protein 26;Nucleotide-binding oligomerization domain protein 5;Nucleotide-binding oligomerization domain protein 9)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79671
Human Swissprot No.
Q86UT6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86UT6/entry
Mouse Swissprot No.
Q3TL44
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q3TL44
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5FVQ8
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human NLRX1. AA range:581-630
特异性
NLRX1 Polyclonal Antibody detects endogenous levels of NLRX1
稀释度
WB 1:500-2000, IHC-p 1:50-300, ELISA 1:10000-20000. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013],
组织表达
Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).
细胞定位
Mitochondrion outer membrane .
信号通路
RIG-I-like receptor;
功能
function:Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).,sequence caution:Translated as Trp.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the NLRP family.,similarity:Contains 1 NACHT domain.,similarity:Contains 4 LRR (leucine-rich) repeats.,subunit:Interacts with MAVS.,tissue specificity:Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HELA, 293T, THP-1, HL60, RAJI, and JURKAT cell lines (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
