产品名称
Plasminogen receptor Rabbit Polyclonal Antibody
别名
Plasminogen receptor (KT) (Plg-R(KT))
蛋白名称
Plasminogen receptor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55848
Human Swissprot No.
Q9HBL7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HBL7/entry
Mouse Swissprot No.
Q9D3P8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9D3P8
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941D4ACN8
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PLGRKT. AA range:1-50
特异性
Plasminogen receptor Polyclonal Antibody detects endogenous levels of Plasminogen receptor
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo.
组织表达
Expressed in peripheral blood cells and monocytes. Expressed in adrenal medulla.
细胞定位
Cell membrane ; Multi-pass membrane protein . Colocalizes on the cell surface with urokinase plasminogen activator surface receptor/PLAUR. .
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
