BD-PT5800

C8 β Rabbit Polyclonal Antibody

Complement component C8 beta chain (Complement component 8 subunit beta)

常规抗体

C8B

C8 β

WB

Human,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

732

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=732

P07358

http://www.uniprot.org/uniprotkb/P07358/entry

110382

Q8BH35

http://www.uniprot.org/uniprot/Q8BH35

P55314

http://www.uniprot.org/uniprot/O54941P55314

The antiserum was produced against synthesized peptide derived from the Internal region of human C8B. AA range:371-420

C8 β Polyclonal Antibody detects endogenous levels of C8 β

WB 1:500-2000, ELISA 1:10000-20000

70kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],

Liver,Plasma,

Secreted.

Complement and coagulation cascades;Prion diseases;Systemic lupus erythematosus;

disease:Defects in C8B are a cause of complement C8 deficiency type II [MIM:120960]. Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.,function:C8 is a constituent of the membrane attack complex. C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9.,online information:C8B mutation db,polymorphism:The sequence shown is that of allotype C8B B.,PTM:N-glycosylated; contains one or two bound glycans. Not O-glycosylated.,similarity:Belongs to the complement C6/C7/C8/C9 family.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 MACPF domain.,similarity:Contains 2 TSP type-1 domains.,subunit:C8 is composed of three chains: alpha, beta and gamma. The beta chain binds to the C8 alpha chain and to the C5b-C7 complex, presumably to C5b. It is essential to the incorporation of C8 into the C5b-C8 complex.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.