产品名称
PJVK Rabbit Polyclonal Antibody
别名
Pejvakin (Autosomal recessive deafness type 59 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.23% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/494513
Human Swissprot No.
Q0ZLH3
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q0ZLH3/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/381375
Mouse Swissprot No.
Q0ZLH2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q0ZLH2
免疫原
Synthesized peptide derived from human PJVK AA range: 69-119
特异性
This antibody detects endogenous levels of PJVK at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a member of the gasdermin family, a family which is found only in vertebrates. The encoded protein is required for the proper function of auditory pathway neurons. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59). [provided by RefSeq, Dec 2008],
细胞定位
Peroxisome membrane . Cell projection, cilium . Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane. Localizes to ciliary rootlet. .
功能
disease:Defects in PJVK are the cause of non-syndromic sensorineural deafness autosomal recessive type 59 (DFNB59) [MIM:610220]. DFNB59 is a form of sensorineural hearing impairment with absent or severely abnormal auditory brainstem response but normal otoacoustic emissions (auditory neuropathy or auditory dys-synchrony). Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.,function:Essential in the activity of auditory pathway neurons.,miscellaneous:'Pejvakin' means 'echo' in Persian.,similarity:Belongs to the gasdermin family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
