产品名称
PTH-rP Rabbit Polyclonal Antibody
别名
Parathyroid hormone-related protein (PTH-rP) (PTHrP) (Parathyroid hormone-like protein) (PLP) [Cleaved into: PTHrP[1-36]; PTHrP[38-94]; Osteostatin (PTHrP[107-139])]
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5744
Human Swissprot No.
P12272
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P12272/entry
Mouse Swissprot No.
P22858
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P22858
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human PTHLH. AA range:101-150
特异性
PTH-rP Polyclonal Antibody detects endogenous levels of PTH-rP
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
parathyroid hormone like hormone(PTHLH) Homo sapiens The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013],
组织表达
Ubiquitous. Also expressed in the mammary gland.
细胞定位
Cytoplasm. Nucleus. Secreted.
功能
alternative products:Additional isoforms seem to exist,disease:Produced by many tumors from patients with HHM (humoral hypercalcemia of malignancy).,function:Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth.,function:Osteostatin is a potent inhibitor of osteoclastic bone resorption.,PTM:There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions.,similarity:Belongs to the parathyroid hormone family.,tissue specificity:Ubiquitous. Also expressed in the mammary gland.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
