BD-PT5788

Nanos Homologue 1 (NANOS1) Rabbit Polyclonal Antibody

Nanos homolog 1 (NOS-1) (EC_Rep1a)

常规抗体

NANOS1

Nanos Homologue 1 (NANOS1)

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

340719

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=340719

Q8WY41

http://www.uniprot.org/uniprotkb/Q8WY41/entry

332397

Q80WY3

http://www.uniprot.org/uniprot/Q80WY3

Synthesized peptide derived from Nanos Homologue 1 (NANOS1) at AA range: 151-200

Nanos Homologue 1 (NANOS1) Polyclonal Antibody detects endogenous levels of Nanos Homologue 1 (NANOS1)

WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000

30kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015],

Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness.

Cytoplasm, perinuclear region . Cytoplasm . Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. .

domain:The Nanos-type zinc finger is composed of two C2HC motifs, each motif binding one molecule of zinc. It is essential for the translation repression activity of the protein.,function:May regulate translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets.,similarity:Belongs to the nanos family.,similarity:Contains 1 nanos-type zinc finger.,subunit:Interacts with PUM2.,tissue specificity:Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.