产品名称
CYFIP2 Rabbit Polyclonal Antibody
别名
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26999
Human Swissprot No.
Q96F07
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96F07/entry
Mouse Swissprot No.
Q5SQX6
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q5SQX6
免疫原
Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
特异性
CYFIP2 Polyclonal Antibody detects endogenous levels of CYFIP2
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
组织表达
Expressed in T-cells. Increased expression is observed in CD4(+) T-lymphocytes from patients with multiple sclerosis (at protein level).
细胞定位
Cytoplasm . Nucleus . Cytoplasm, perinuclear region . Cell junction, synapse, synaptosome . Highly expressed in the perinuclear regionand enriched in synaptosomes (By similarity). Treatment with leptomycin-B triggers translocation to the nucleus (PubMed:17245118). .
信号通路
Regulates Actin and Cytoskeleton;
功能
disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
