BD-PT5779

MIA2 Rabbit Polyclonal Antibody

Melanoma inhibitory activity protein 2

常规抗体

MIA2

MIA2

WB

Human,Rat,Mouse

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

117153

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117153

Q96PC5

http://www.uniprot.org/uniprotkb/Q96PC5/entry

338320

Q91ZV0

http://www.uniprot.org/uniprot/Q91ZV0

Synthesized peptide derived from MIA2 at AA range: 361-410

MIA2 Polyclonal Antibody detects endogenous levels of MIA2

WB 1:500-2000;IHC-p 1:50-300

65kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016],

Highly expressed in liver and weakly in testis. Expression was higher in patients with severe fibrosis or inflammation and chronic hepatitis (PubMed:12586826). Isoform 1 is specifically expressed in lung, testis, small intestine, colon, pancreas, kidney, liver and prostate (PubMed:27138255). Isoform 8 is expressed only in testis (at the protein level). Isoform 8 (at protein level) and isoform 9 are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 9, but not isoform 5A, is expressed in head and neck squamous cell carcinoma (PubMed:12839582).

Endoplasmic reticulum membrane ; Single-pass membrane protein . Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). .

disease:Autoantigen found several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL). Isoform 5A and isoform 5B are recognized by patients' sera with tumor specimen of various origins.,disease:Tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL). Also found in colorectal and breast carcinomas, head and neck squamous cell carcinomas and melanoma.,function:Tumor-associated antigen.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the cTAGE family.,tissue specificity:At the protein level, isoform 5A is expressed only in testis. Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at the protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.,tissue specificity:Expressed in testis, placenta and skin. Expressed at lower level in mammary gland and stomach.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.