产品名称
TRAF1 Rabbit Polyclonal Antibody
别名
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7185
Human Swissprot No.
Q13077
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q13077/entry
Mouse Swissprot No.
P39428
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P39428
免疫原
Synthesized peptide derived from TRAF1 at AA range: 191-240
特异性
TRAF1 Polyclonal Antibody detects endogenous levels of TRAF1
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
TNF receptor associated factor 1(TRAF1) Homo sapiens The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have
组织表达
Lymphoma,Skin,Spleen,Stomach,
信号通路
Pathways in cancer;Small cell lung cancer;
功能
domain:The coiled coil domain mediates homo- and hetero-oligomerization.,domain:The MATH/TRAF domain binds to receptor cytoplasmic domains.,function:Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.,similarity:Contains 1 MATH domain.,subunit:Homotrimer (Probable). Heteromer with TRAF2 and associates with TNFRSF1B/TNFR2 through TRAF2. Associates with TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus. Interacts wtih NFATC2IP and with HIVEP3.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
