产品名称
GABARAP Rabbit Polyclonal Antibody
别名
GABA(A) receptor-associated protein-like 2
基因名称
GABARAPL2 FLC3A GEF2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11345
Human Swissprot No.
P60520
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P60520/entry
Mouse Swissprot No.
P60521
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P60521
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941P60522
免疫原
Synthetic Peptide of GABARAP AA range: 26-75
特异性
GABARAP Polyclonal Antibody detects endogenous levels of GABARAP
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 LC3 family.,subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.,tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,
组织表达
Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.
细胞定位
Cytoplasmic vesicle, autophagosome . Endoplasmic reticulum membrane . Golgi apparatus .
信号通路
Regulation of autophagy;
功能
function:Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MAP1 LC3 family.,subunit:Monomer. Interacts with GABRG2, NSF, GOSR1 and beta-tubulin (By similarity). Interacts with ULK1.,tissue specificity:Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
