产品名称
Atg9a Rabbit Polyclonal Antibody
别名
ATG9 autophagy related 9 homolog A (S. cerevisiae)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79065
Human Swissprot No.
Q7Z3C6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q7Z3C6/entry
Mouse Swissprot No.
Q68FE2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q68FE2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q5FWU3
免疫原
Synthetic Peptide of Atg9a
特异性
Atg9a Polyclonal Antibody detects endogenous levels of Atg9a
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Plays a role in autophagy.,similarity:Belongs to the ATG9 family.,
组织表达
Brain,Embryo,Epithelium,Fetal brain,Lung endothelial cell,Lymph,Rectum tumor,Testis
细胞定位
Preautophagosomal structure membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, autophagosome membrane ; Multi-pass membrane protein . Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Recycling endosome membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Mitochondrion membrane ; Multi-pass membrane protein . Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27316455, PubMed:27663665). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex (PubMed:29180427, PubMed:30262884). Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS) (PubMed:16940348). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1 (PubMed:16940348). Upon autophagy induction, a small portion transiently localizes to the autophagic membranes (PubMed:22456507). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (PubMed:34432599). .
功能
function:Plays a role in autophagy.,similarity:Belongs to the ATG9 family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.