产品名称
RHEB Rabbit Polyclonal Antibody
别名
Ras homolog enriched in brain
反应种属
Human,Mouse,Rat,Predicted:Cow
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6009
Human Swissprot No.
Q15382
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15382/entry
Mouse Swissprot No.
Q921J2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q921J2
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q62639
免疫原
Synthetic Peptide of RHEB
特异性
This antibody detects endogenous levels of RHEB Polyclonal Antibody at Human;Mouse;Rat;Predicted:Cow, It doesn't reacte with total protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008],
组织表达
Ubiquitous. Highest levels observed in skeletal and cardiac muscle.
细胞定位
Endomembrane system ; Lipid-anchor ; Cytoplasmic side . Golgi apparatus membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Lipid-anchor ; Cytoplasmic side .
信号通路
mTOR;Insulin_Receptor;
功能
function:Not known; binds GTP and exhibits intrinsic GTPase activity.,similarity:Belongs to the small GTPase superfamily. Rheb family.,tissue specificity:Ubiquitous. Highest levels observed in skeletal and cardiac muscle.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.