产品名称
BMP-10 Rabbit Polyclonal Antibody
别名
bone morphogenetic protein 10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27302
Human Swissprot No.
O95393
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O95393/entry
Mouse Swissprot No.
Q9R229
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9R229
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q4AEG6
免疫原
Synthesized peptide derived from BMP-10 at AA range: 361-410
特异性
BMP-10 Polyclonal Antibody detects endogenous levels of BMP-10
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. [provided by RefSeq, Aug 2016],
组织表达
Detected in mammary epithelia (at protein level).
功能
function:Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.,online information:Bone morphogenetic protein 10 entry,similarity:Belongs to the TGF-beta family.,subunit:Homodimer; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
