产品名称
CD238 Rabbit Polyclonal Antibody
别名
Kell blood group, metallo-endopeptidase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3792
Human Swissprot No.
P23276
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P23276/entry
Mouse Swissprot No.
Q9EQF2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9EQF2
免疫原
The antiserum was produced against synthesized peptide derived from the Internal region of human KEL. AA range:351-400
特异性
CD238 Polyclonal Antibody detects endogenous levels of CD238
稀释度
WB 1:500-2000, ELISA 1:10000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a type II transmembrane glycoprotein that is the highly polymorphic Kell blood group antigen. The Kell glycoprotein links via a single disulfide bond to the XK membrane protein that carries the Kx antigen. The encoded protein contains sequence and structural similarity to members of the neprilysin (M13) family of zinc endopeptidases. [provided by RefSeq, Jul 2008],
组织表达
Expressed at high levels in erythrocytes and testis (in Sertoli cells), and, at lower levels, in skeletal muscle, tonsils (in follicular dendritic cells), lymph node, spleen and appendix (at protein level). Also expressed in many adult and fetal nonerythroid tissues, including brain, spleen, lymph nodes and bone marrow.
细胞定位
Cell membrane; Single-pass type II membrane protein. Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.
功能
cofactor:Binds 1 zinc ion per subunit.,function:Zinc endopeptidase with endothelin-3-converting enzyme activity.,online information:Blood group antigen gene mutation database,polymorphism:KEL is responsible for the Kell blood group system. The molecular basis of the K=KEL1/k=KEL2 blood group antigens is a single variation in position 193; Thr-193 corresponds to KEL2 and Met-193 to KEL1. The molecular basis of the Kpa=KEL3/Kpb=KEL4/Kpc=KEL21 blood group antigens is a single variation in position 281; Arg-281 corresponds to KEL4, Trp-281 to KEL3 and Gln-281 to KEL21. The molecular basis of the Jsa=KEL6/Jsb=KEL7 blood group antigens is a single variation in position 597; Leu-597 corresponds to KEL7 and Pro-597 to KEL6. The molecular basis of the KEL11/KEL17 blood group antigens is a single variation in position 302; Val-302 corresponds to KEL11 and Ala-302 to KEL17. The molecular basis of the KEL14/KEL24 blood group antigens is a single variation in position 180; Arg-180 corresponds to KEL14 and Pro-180 to KEL24.,similarity:Belongs to the peptidase M13 family.,subcellular location:Spans the erythrocyte membrane, and is attached to the underlying cytoskeleton.,subunit:Heterodimer with XK; disulfide-linked.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
