产品名称
IGHA1 Rabbit Polyclonal Antibody
别名
Ig alpha-1 chain C region
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.35% New type preservative N.
Human Swissprot No.
P01876
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P01876/entry
免疫原
Synthesized peptide derived from human IGHA1 AA range: 118-168
特异性
This antibody detects endogenous levels of IGHA1 at Human
宿主
Polyclonal, Rabbit,IgG
组织表达
Bile,Colon,Mammary gland,Stomach mucosa,
细胞定位
Secreted . Cell membrane .
功能
disease:A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.,function:Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.,PTM:3-Hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with alpha-1-microglobulin to form heterogeneous polycyclic chromophores including hydroxanthommatin. The chromophore reacts with accessible cysteines forming non-reducible thioether cross-links with Ig alpha-1 chain C region Cys-352.,similarity:Contains 3 Ig-like (immunoglobulin-like) domains.,subunit:Monomeric or polymeric.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
