产品名称
C32 Rabbit Polyclonal Antibody
别名
CKLF; CKLF1; HSPC224; Chemokine-like factor; C32
蛋白名称
Chemokine-like factor
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=51192
Human Swissprot No.
Q9UBR5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UBR5/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75458
Mouse Swissprot No.
Q9DAS1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9DAS1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245978
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JK79
免疫原
Synthesized peptide derived from Chemokine-like factor at AA range: 103-152
特异性
C32 Polyclonal Antibody detects endogenous levels of C32 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011],
组织表达
Isoform 1, isoform 2, isoform 3 and isoform 4 have highest expression levels in adult spleen, lung, testis, ovary, peripheral blood leukocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate and fetal spleen and liver.
细胞定位
[Isoform 1]: Secreted .; [Isoform 2]: Membrane ; Multi-pass membrane protein .; [Isoform 4]: Membrane ; Multi-pass membrane protein .
功能
function:Isoform CKLF1 has chemotactic response in rat monocytes, neutrophils, and lymphocytes.,function:May play an important role in inflammation and regeneration of skeletal muscle. Partly inhibited by interleukin 10.,similarity:Belongs to the chemokine-like factor family.,similarity:Contains 1 MARVEL domain.,tissue specificity:All 4 isoforms have highest expression levels in adult spleen, lungs, testis, ovary, peripheral blood leucocyte, placenta, pancreas, and in fetal brain, skeletal muscle, thymus and heart. Lower expression levels in adult skeletal muscle, liver, thymus colon, prostate, and fetal spleen and liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
